Highly specific synaptic plasticity in addiction

Addiction, or substance use disorder (SUD), is a complex neurological condition that includes drug-seeking behavior among other cognitive, emotional and behavioral features. Synaptic plasticity, or changes in the way neurons communicate with one another, drives these addictive behaviors. A new study in Biological Psychiatry, published by Elsevier, now shows that players in the extracellular environment – not just at neuronal interfaces – contribute to addiction plasticity.