Scientists establish first lethal mouse model for COVID-19

Army scientists have developed the first lethal mouse model of SARS-CoV-2, the virus that causes COVID-19, using mice that were genetically engineered to express the human ACE2 gene — a key mechanism by which the virus enters human cells. In addition to shedding light on the pathogenesis of COVID-19, this work directly contributes to the advancement of medical countermeasures against the virus.