Tethering together type 2 diabetes drugs increases efficacy of combination therapy

Biomedical engineers at Duke University have shown that the effectiveness of a two-pronged type 2 diabetes treatment increases when the drugs are linked by a heat-sensitive tether rather than concurrently administered. The combination molecule forms a gel-like depot under the skin that slowly releases the drug. These findings suggest that this approach to combination drug design could be applied to disease therapies beyond diabetes.