Blocking cellular communication stops SARS-CoV-2

Many viruses use and manipulate the communication pathways of their host cells to boost their own replication. Now biochemists and virologists from Goethe University and University Hospital Frankfurt have drawn a complete picture of communication within human cells infected with SARS-CoV-2. In cell culture experiments, the researchers succeeded in stopping virus replication with a series of cancer drugs tested in clinical practice. The drugs target the places where several of the cell’s communication pathways meet.