Lipid-oligonucleotides (LONs) are promising biological materials with special amphiphilic structures and unique functionalities of two moieties, contributing to different bioapplications (from biosensors to biomedicines). LONs have been employed in cellular microenvironment monitoring and mechanical forces measurements, and have shown potential in developing targeted theranostics as well as controllable nanoreactors. This review will discuss the recent progress of using LONs in various bioapplications and the remaining challenges, while leaving some suggestions for future improvement.
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