Shigella prevents infected cells from sacrificing themselves for the greater good

Researchers from Tokyo Medical and Dental University (TMDU) investigated how Shigella survive and multiply to cause severe inflammatory colitis. By screening several effector proteins that Shigella inject into colon cells, the researchers identified the effector proteins OspC1 and OspD3 as molecular measures through which Shigella inhibit both apoptosis and necroptosis. These findings help understand the molecular mechanisms of bacterial infections of the intestinal system.