A cancer mystery of more than 40 years ago is solved thanks to epigenetics

In an article that was just published in Proceedings of the National Academy of Sciences (PNAS) by the group of Dr. Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, ICREA Research Professor and Professor of Genetics at the University of Barcelona is solved this mystery by describing that in cancer cells the protein that generates the nucleotide “Y” is epigenetically inactivated, causing small but highly aggressive tumors.