Mathematical modeling revealed how chitinase, a molecular monorail, obeys a one-way sign

A novel mathematical modeling method has been developed to estimate operation models of biomolecular motors from single-molecule imaging data of motion with the Bayesian inference framework. The operation mechanism of a linear molecular motor “chitinase”, which moves one-way on a chitin chain with degrading the chain passed by, was elucidated by mathematical modeling of experimental imaging data with the method.