Both osteoblasts and osteoclasts are necessary for fracture repair. While osteoblasts are known to control the formation and activity of osteoclasts, the inter-cellular signaling involved in this process is not fully understood. Researchers led by Kanazawa University have now shown that osteoblast-derived extracellular vesicles containing signaling molecule RANKL are taken up by immature osteoclasts, triggering maturation. An understanding of osteoblast-osteoclast communication is the first step in developing effective therapies for metabolic and genetic bone diseases.
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