Messages sent by osteoblasts to osteoclasts are enclosed in an extracellular vesicle

Both osteoblasts and osteoclasts are necessary for fracture repair. While osteoblasts are known to control the formation and activity of osteoclasts, the inter-cellular signaling involved in this process is not fully understood. Researchers led by Kanazawa University have now shown that osteoblast-derived extracellular vesicles containing signaling molecule RANKL are taken up by immature osteoclasts, triggering maturation. An understanding of osteoblast-osteoclast communication is the first step in developing effective therapies for metabolic and genetic bone diseases.