Mouse model identified to study common form of heart failure linked to age-related obesity

A research team led by the USF Health Heart Institute, University of South Florida, identified a mouse model that thoroughly mimics HFpEF syndrome in humans. These obesity-prone mice lack the inflammation clearing receptor ALX/FPR2 — a deficiency previously shown to drive cardiac and kidney inflammation in aging mice. The team defines the essential role this receptor plays in safely clearing unresolved cardiac inflammation and proposes it may offer targets for treating HFpEF, a prevelant and challenging form of heart failure.