RNA structures by the thousands

Researchers from Bochum and Münster have developed a new method to determine the structures of all RNA molecules in a bacterial cell at once. In the past, this had to be done individually for each molecule. Besides their exact composition, their structure is crucial for the function of the RNAs. The team describes the new high-throughput structure mapping method, termed Lead-Seq for lead sequencing, in the journal Nucleic Acids Research, published online on 28 May 2020.