SLC35B1 as a key modulator of a UDPGA transporter into the endoplasmic reticulum

Researchers from Kanazawa University identified SLC35B1 as a key regulator of the glucuronidation process in the human liver. By using HepaRG cells, a human liver cell line, and human liver samples, they showed that among a panel of SLC35 proteins SLC35B1 most significantly contributed to glucuronidation. These findings indicated that the large interindividual differences in SLC35B1 expression may be an additional factor contributing to the interindividual differences in glucuronidation.