Scientists reveal relationship between Dek and Intron retention during muscle stem cells quiescence

Adult stem cells are essential for tissue regeneration. However, the mechanisms underlying the activation of quiescent adult stem cells remain elusive. Recently, a team of HKUST scientists revealed that intron detention (IR) is a key to the mechanism; when stem cell enters quiescence exit, Dek releases conserved introns, which allow the cell to be activated.