Uncuffing nitric oxide production: Beta-arrestin2 complexes regulate NO levels

In a new report, researchers at the Medical University of South Carolina have uncovered one of the mechanisms regulating the production of nitric oxide (NO) in liver endothelial cells. A protein complex, centered around beta-arrestin2, modulates endothelial nitric oxide synthase activity and may provide a novel therapeutic target to restore NO production following liver injury.