Squid studies illuminate neural dysfunction in ALS; suggest new route to therapy

Yuyu Song of Harvard Medical School was a Grass Fellow at the Marine Biological Laboratory (MBL) when she took advantage of a powerful research organism in neuroscience, the local squid, to start asking how a mutant protein associated with familial ALS behaves under controlled conditions. Her study, recently published in eNeuro, clarifies the mechanisms underlying neural dysfunction in ALS, and also suggests a novel approach to restoring the health of motor neurons in patients with the disease.