Mouse model mimics SARS-CoV-2 infection in humans

A mouse model of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reproduces features observed in human patients, researchers report May 26 in the journal Cell Host & Microbe. Using CRISPR/Cas9 gene editing technology, the researchers generated mice that produce human angiotensin-converting enzyme II (hACE2)–the receptor that SARS-CoV-2 binds to and uses to enter human cells.