What if we could design powerful drugs without unwanted side effects?

The paper describes how to minimize or eliminate side effects in drugs that target G protein-coupled receptors. GPCRs are proteins found in all human cells. LSD and other psychedelics are molecules that attach to GPCRs, as are about a third of prescription drugs, including antihistamines, beta blockers and opioids. ‘Armed with our results, researchers can begin to imagine new and better ways to design drugs that retain their effectiveness while posing fewer dangers.’