Missing component of innate immune signaling identified

Giulio Superti-Furga’s group at CeMM in partnership with Charles Whitehurst and JangEun Lee’s team at Boehringer Ingelheim have identified a new key element of the multi-component machinery responsible for sorting out the nature and severity of the pathogen challenge. The new protein, named TASL, is indispensable for the signaling of so-called Toll-like receptors (TLR) in the endosomes leading to activation of the gene-activator IRF5 in certain immune cells. The study has been published in Nature.