New therapeutic targets for treating memory impairment in Down syndrome

Researchers from Hospital del Mar Medical Research Institute studied the neural basis of intellectual disability in mice with Down syndrome and discovered that the neural networks of brain circuits relevant to memory and learning are over-activated and that the connectivity of these circuits is poor. They also identified biomarkers in brain rhythms that can predict memory deficits in the mice which are corrected by chronic treatment with a natural component of green tea, epigallocatechin gallate