Proteasome phase separation for destruction

Researchers at the Tokyo Metropolitan Institute of Medical Science (TMiMS) discovered proteasome-containing droplets, which are formed by acute hyperosmotic stress. The proteasome droplets also contain ubiquitin-tagged proteins and multiple interacting proteins, by which induce liquid-liquid phase separation of the proteasome for rapid degradation of unwanted proteins. The ubiquitin-dependent proteasome phase separation may be linked to clearance of aggregates that causes neurodegenerative diseases. These results were published in Nature.