A ‘corset’ for the enzyme structure

The structure of enzymes determines how they control vital processes such as digestion or immune response. This is because the protein compounds are not rigid, but can change their shape through movable ‘hinges.’ The shape of enzymes can depend on whether their structure is measured in the test tube or in the living cell. This is what physicochemists at the University of Bonn discovered about YopO, an enzyme of the plague pathogen.